The 2026 NFL Kickoff Game will feature the same matchup which closed out last season as the Super Bowl champion Seattle Seahawks host the New England Patriots. The contest takes place on Wednesday, Sep. 9, marking the second time that the NFL Kickoff Game won't be held on a Thursday. Seattle is coming off a 14-3 regular season, which culminated in a 29-13 victory over the Pats in The Big Game. New England also went 14-3 in the regular season in Mike Vrabel's first year as head coach of the team. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in wagers here:
Kickoff is set for 8:20 p.m. ET from Lumen Field in Seattle. The Seahawks have won each of the last four meetings. The latest Seahawks vs. Patriots odds have Seattle as 3.5-point favorites, while the over/under for total points scored is 44.5. Before making any Patriots vs. Seahawks picks or 2026 NFL Kickoff Game predictions, be sure to see what the SportsLine projection model has to say.
The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the 2026 NFL season on a 53-37 run on top-rated picks dating back to 2024. Anybody following its NFL betting picks at sportsbooks and on betting sites could have seen strong returns.
Now, the model has zoned in on Seahawks vs. Patriots. You can head to SportsLine now to see its picks. Here are several NFL odds and betting lines for Patriots vs. Seahawks:
Seahawks vs. Patriots spread
Seattle -3.5
Seahawks vs. Patriots over/under
44.5 points
Seahawks vs. Patriots money line
Seattle -201, New England +167
Seahawks vs. Patriots picks
Seahawks vs. Patriots streaming
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Top Patriots vs. Seahawks predictions
After 10,000 simulations of Seahawks vs. Patriots, the model is going Over 44.5 points. These were two of the top three scoring offenses last season, and each upgraded those units in the offseason. New England added three-time All-Pro A.J. Brown, in addition to using its first round pick on an offensive tackle to help protect Drake Maye. As for Seattle, Kenneth Walker III's departure means more of Zach Charbonnet, who is an endzone magnet. He had more than twice as many touchdowns as Walker last year, despite 48 fewer carries, and Seattle also drafted former Notre Dame RB Jadarian Price in the first round.
The Over had a 7-2 record when Seattle was a home favorite last year, which was the best mark in the league (min. three games). Meanwhile, the Over went 11-6 in Patriots' regular season contests in 2025, which was tied for the second-best record in the NFL. Given those trends, and the fact that the Over has hit in each of the last six regular-season meetings between these teams, the model foresees the total being eclipsed. It projects 46 combined points, giving value to the Over. See which team to back at SportsLine.
How to make Seahawks vs. Patriots picks
For Patriots vs. Seahawks in the NFL Kickoff Game, the model says one side of the spread is hitting in well over 60% of simulations. See what it is at SportsLine.
Who covers in Seahawks vs. Patriots, and which side of the spread hits well over 60% of the time? Visit SportsLine now to see which side of the Patriots vs. Seahawks spread you need to jump, all from the model that's on a 53-37 run on top-rated picks since 2024, and find out.
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